タイトル | Mechanism of read-through enhancement by aminoglycosides and mefloquine |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Year 2025 |
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掲載日 | 2023年3月20日 (構造データの登録日) |
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著者 | Kolosova O / Zgadzay Y / Yusupov M |
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リンク | Proc. Natl. Acad. Sci. USA / PubMedで検索 |
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手法 | EM (単粒子) / X線回折 |
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解像度 | 2.9 - 3.5 Å |
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構造データ | EMDB-16874, PDB-8ogj: Structure of Candida albicans 80S ribosome in complex with mefloquine 手法: EM (単粒子) / 解像度: 3.1 Å PDB-8cq7: Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-8cqw: Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B 手法: X-RAY DIFFRACTION / 解像度: 3.05 Å PDB-8cre: Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-8oeq: Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM) 手法: X-RAY DIFFRACTION / 解像度: 3.3 Å PDB-8oh6: Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol) 手法: X-RAY DIFFRACTION / 解像度: 3.35 Å PDB-8oi5: Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM) 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-8oj3: Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state) 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å |
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化合物 | ChemComp-3K5: 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose
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由来 | candida albicans (酵母) candida (菌類)
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キーワード | RIBOSOME / Candida albicans / phyllanthoside / hygromycin B / geneticin / G418 / paromomycin / mefloquine / PTC read-through |
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