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Structure paper

TitleStructural basis for the full and partial agonist activities of retinoid X receptor alpha ligands with an iso-butoxy and an isopropyl group
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 734, Page 150617-, Year 2024
Publish dateNov 13, 2019 (structure data deposition date)
AuthorsImai, D. / Numoto, N. / Tokiwa, H. / Kakuta, H. / Ito, N.
External linksBiochem. Biophys. Res. Commun. / Search PubMed
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-6lb5:
Crystal structure of dimeric RXR-LBD complexed with full agonist NEt-3IB and TIF2 co-activator
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6lb6:
Crystal structure of dimeric RXR-LBD complexed with partial agonist NEt-4IB and TIF2 co-activator
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-E80:
6-[ethyl-[3-(2-methylpropoxy)-4-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid

ChemComp-HOH:
WATER

ChemComp-E8O:
6-[ethyl-[4-(2-methylpropoxy)-3-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / NUCLEAR RECEPTOR / RETINOID X RECEPTOR alpha / Active form / co-factors / partial agonist

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