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Author
Journal
IF

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Structure paper

TitleMolecular glues that facilitate RAS binding to PI3Kalpha promote glucose uptake without insulin
Journal, issue, pagesScience, Year 2025
Publish dateJul 15, 2024 (structure data deposition date)
AuthorsCzyzyk, D.J. / Yan, W. / Messing, S. / Gillette, W. / Esposito, D. / Nissley, D.V. / McCormick, F. / Simanshu, D.K.
External linksScience / Search PubMed
MethodsX-ray diffraction
Resolution1.75 - 3.01 Å
Structure data

PDB-9cmk:
Crystal structure of p110alpha-RAS binding domain (RBD) in complex with molecular glue D927
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-9cml:
Crystal structure of p110alpha-RAS binding domain (RBD) in complex with molecular glue D223
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

PDB-9cmv:
Crystal structure of the KRAS-p110alpha complex in the presence of molecular glue D223
Method: X-RAY DIFFRACTION / Resolution: 3.01 Å

Chemicals

PDB-1atf:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

PDB-1azd:
CONCANAVALIN FROM CANAVALIA BRASILIENSIS

ChemComp-GOL:
GLYCEROL

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / RAS / PI3Kalpha / p110alpha / PIK3CA / RBD / glue / D927 / D223 / oncoprotein / KRAS / inducer compound

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