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-Structure paper
Title | The PDE inhibition profile of LY294002 and tetrahydropyranyl analogues reveals a chromone motif for the development of PDE inhibitors |
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Journal, issue, pages | To be Published |
Publish date | Jan 15, 2014 (structure data deposition date) |
Authors | Howard, B.L. / Nankervis, J.L. / Feil, S.C. / Manallack, D.T. / Holien, J.K. / Zhen, Z. / Jennings, I.G. / Abbott, B.M. / Parker, M.W. / Thompson, P.E. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.032 Å |
Structure data | PDB-4ogb: |
Chemicals | ChemComp-2SR: ChemComp-EDO: ChemComp-PEG: ChemComp-ZN: ChemComp-DMS: ChemComp-EPE: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / CATALYTIC MECHANISM / CAMP HYDROLYSIS / HYDROLASE-INHIBITOR COMPLEX / HYDROLASE-HYDROLASE INHIBITOR complex |