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TitleDiscovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor
Journal, issue, pagesJ. Med. Chem., Vol. 63, Page 5477-5487, Year 2020
Publish dateJun 5, 2019 (structure data deposition date)
AuthorsShen, Y. / Li, F. / Szewczyk, M.M. / Halabelian, L. / Park, K.S. / Chau, I. / Dong, A. / Zeng, H. / Chen, H. / Meng, F. ...Shen, Y. / Li, F. / Szewczyk, M.M. / Halabelian, L. / Park, K.S. / Chau, I. / Dong, A. / Zeng, H. / Chen, H. / Meng, F. / Barsyte-Lovejoy, D. / Arrowsmith, C.H. / Brown, P.J. / Liu, J. / Vedadi, M. / Jin, J.
External linksJ. Med. Chem. / Search PubMed
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-6p7i:
Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-O3P:
N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide

ChemComp-GOL:
GLYCEROL

ChemComp-O3S:
N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]propanamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Protein arginine methyltransferase / PRMT6 / HRMT1L6 / PRMT inhibitors / Structural Genomics / Structural Genomics Consortium / SGC / Transferase-Transferase Inhibitor complex

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