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| Title | The Herpes simplex Origin Binding Protein: Mechanisms for sequence specific DNA binding and dimerization revealed by Cryo-EM |
|---|---|
| Journal, issue, pages | Nucleic Acids Res., Year 2025 |
| Publish date | Nov 19, 2024 (structure data deposition date) |
Authors | Gustavsson E / Grunewald K / Elias P / Hallberg BM |
External links | Nucleic Acids Res. / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.74 - 4.38 Å |
| Structure data | EMDB-52135, PDB-9hgi: ![]() EMDB-52136: Focused map of HSV-1 Origin Binding Protein monomer A in complex with double-stranded DNA recognition sequence OriS with 6 basepairs removed from the AT-rich region ![]() EMDB-52137: Focused map of HSV-1 Origin Binding Protein monomer B in complex with double-stranded DNA recognition sequence OriS with 6 basepairs removed from the AT-rich region EMDB-52145, PDB-9hgj: ![]() EMDB-52146: Composite map of HSV-1 Origin Binding Protein tetramer in complex with single-stranded DNA recognition sites Box 1 and Box 3 with 10 dT-tail ![]() EMDB-52147: Consensus map of HSV-1 Origin Binding Protein tetramer in complex with single-stranded DNA recognition sites Box 1 and Box 3 with 10 dT-tail ![]() EMDB-52148: Focused map of dimer 1 in HSV-1 Origin Binding Protein tetramer in complex with single-stranded DNA recognition sites Box 1 and Box 3 with 10 dT-tail ![]() EMDB-52149: Focused map of dimer 2 of HSV-1 Origin Binding Protein tetramer in complex with single-stranded DNA recognition sites Box 1 and Box 3 with 10 dT-tail ![]() EMDB-52150: HSV-1 Origin Binding Protein monomer in complex with hairpin DNA OriS recognition sites Box 1 and Box 3 with 10 dT-tail |
| Chemicals | ![]() ChemComp-AGS: ![]() ChemComp-MG: |
| Source |
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Keywords | DNA BINDING PROTEIN / DNA / Helicase / Complex |
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human alphaherpesvirus 1 strain kos
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