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Structure paper

TitleReciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus
Journal, issue, pagesNat Microbiol, Year 2021
Publish dateJun 13, 2018 (structure data deposition date)
AuthorsShyp, V. / Dubey, B.N. / Bohm, R. / Hartl, J. / Nesper, J. / Vorholt, J.A. / Hiller, S. / Schirmer, T. / Jenal, U.
External linksNat Microbiol / Search PubMed
MethodsX-ray diffraction
Resolution2.8 - 3.3 Å
Structure data

PDB-6gs8:
Crystal structure of SmbA in complex with c-di-GMP
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6gtm:
Crystal structure of SmbA in complex with ppGpp.
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-C2E:
9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-G4P:
GUANOSINE-5',3'-TETRAPHOSPHATE

Source
  • caulobacter vibrioides (strain atcc 19089 / cb15) (bacteria)
KeywordsSIGNALING PROTEIN / c-di-GMP receptor / ppGpp / second messenger / TIM barrel / ppGpp receptor

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