タイトル | A two-metalloenzyme cascade constructs the azetidine-containing pharmacophore |
---|
ジャーナル・号・ページ | Nat. Chem., Year 2025 |
---|
掲載日 | 2024年8月6日 (構造データの登録日) |
---|
著者 | Gong, R. / Qu, Y. / Liu, J. / Zhang, X. / Zhou, L. / Tian, Z. / Zeng, X. / Jin, B. / Li, Z. / Yu, L. ...Gong, R. / Qu, Y. / Liu, J. / Zhang, X. / Zhou, L. / Tian, Z. / Zeng, X. / Jin, B. / Li, Z. / Yu, L. / Chen, R. / Zhou, Y. / Liao, L. / Yang, L. / Song, X. / Cai, Y.S. / Shen, K. / Deng, Z. / Zhang, Z. / Wang, B. / Chen, W. |
---|
リンク | Nat. Chem. / PubMedで検索 |
---|
手法 | X線回折 |
---|
解像度 | 1.65 - 2.6 Å |
---|
構造データ | PDB-9j27: Fe-SaPolF-L-isoleucine copmplex 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-9j28: Fe2+-SzPolF-2 complex 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-9j29: Fe/Fe-SzPolF-POIA complex 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-9j2a: Fe/Fe-SzPolF-2 complex 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-9j2b: Fe/Fe-SzPolF-L-isoleucine complex 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-9j2c: Fe-SzPolF-L-isoleucine 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-9j2e: Fe2+/pterin-dependent,apo SnPolE 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-9j2m: Fe2+/pterin-dependent enzyme,BH4-SnPolE complex 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-9j2p: Fe2+/pterin-dependent,BH4-L-isoleucine-SnPolE complex 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-9j2r: Fe2+/pterin-dependent,SnPolE-L-ile complex,Y157A mutation 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-9j30: Fe2+/pterin-dependent,SnPolE-Y280A 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-9j33: Fe2+/pterin-dependent,SnPolE-F140A 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-9j3g: Fe2+/pterin-dependent, apo SmPolE 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-9j3v: Fe2+/Fe2+ PolF-L-isoleucine complex 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å |
---|
化合物 | PDB-1eaj: DIMERIC STRUCTURE OF THE COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR D1 DOMAIN AT 1.35 ANGSTROM RESOLUTION
PDB-1eai: COMPLEX OF ASCARIS CHYMOTRPSIN/ELASTASE INHIBITOR WITH PORCINE ELASTASE
|
---|
由来 | streptomyces armeniacus (バクテリア) streptomyces sp. z26 (バクテリア) streptomyces sp. nth33 (バクテリア) streptomyces sp. ms191 (バクテリア) streptomyces asoensis (バクテリア)
|
---|
キーワード | OXIDOREDUCTASE / nonheme diiron enzyme / an unprecedented nonheme diiron enzyme / Fe2+/pterin-dependent |
---|