+Search query
-Structure paper
Title | Unexpected moves: a conformational change in MutSalpha enables high affinity DNA mismatch binding |
---|---|
Journal, issue, pages | Nucleic Acids Res., Year 2023 |
Publish date | Jul 19, 2022 (structure data deposition date) |
Authors | Bruekner SR / Pieters W / Fish A / Liaci AM / Scheffers S / Rayner E / Kaldenbach D / Drost L / Dekker M / van Hees-Stuivenberg S ...Bruekner SR / Pieters W / Fish A / Liaci AM / Scheffers S / Rayner E / Kaldenbach D / Drost L / Dekker M / van Hees-Stuivenberg S / Delzenne-Goette E / de Konink C / Houllleberghs H / Dubbink HJ / AlSaegh A / de Wind N / Forster F / te Riele H / Sixma TK |
External links | Search PubMed |
Methods | EM (single particle) |
Resolution | 2.8 - 4.1 Å |
Structure data | EMDB-15417, PDB-8ag6: EMDB-15518: human MutSalpha mutant (MSH2-V63E/MSH6) on DNA containing a GT mismatch EMDB-15519: human MutSalpha (MSH2/MSH6) on DNA containing a GT mismatch in the presence of ADP |
Chemicals | ChemComp-MG: ChemComp-ADP: |
Source |
|
Keywords | DNA BINDING PROTEIN / DNA mismatch repair / MMR / MutSa / Lynch Syndrome |