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TitleCryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity
Journal, issue, pagesImmunity, Year 2025
Publish dateFeb 4, 2025 (structure data deposition date)
AuthorsBekkering E / Yoo R / Hailemariam S / Heide F / Ivanochko D / Jackman M / Proellochs N / Stoter R / van Gemert GJ / Maeda A ...Bekkering E / Yoo R / Hailemariam S / Heide F / Ivanochko D / Jackman M / Proellochs N / Stoter R / van Gemert GJ / Maeda A / Yuguchi T / Wanders O / van Daalen R / Inklaar M / Andrade C / Jansen P / Vermeulen M / Bousema T / Takashima E / Rubinstein J / Kooij T / Jore M / Julien JP
External linksSearch PubMed
MethodsEM (single particle) / X-ray diffraction
Resolution1.2 - 3.39 Å
Structure data

48922

9n5i

EMDB-48922, PDB-9n5i:
Endogenous Pfs230D13-14 in complex with Pfs48/45 bound to anti-Pfs48/45 Fabs RUPA-71 and RUPA-44
Method: EM (single particle) / Resolution: 3.39 Å

PDB-9n6u:
Crystal structure of 18F25 malarial antibody
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-9n7k:
Crystal structure of human anti-Pfs48/45 transmission-blocking antibody RUPA-71
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

PDB-9n89:
Crystal structure of 2A2 malarial antibody
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Pfs48/45 / Pfs230 / Malaria / transmission-blocking antibodies / antibody / human transmission-blocking antibodies

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