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TitleCrystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed to the Tem-1 Beta-Lactamase from Escherichia Coli: Evidence on the Mechanism of Action of a Novel Inhibitor Designed by a Computer-Aided Process
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 118, Page 7435-, Year 1996
Publish dateMay 28, 1996 (structure data deposition date)
AuthorsMaveyraud, L. / Massova, I. / Birck, C. / Miyashita, K. / Samama, J.P. / Mobashery, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-1tem:
6 ALPHA HYDROXYMETHYL PENICILLOIC ACID ACYLATED ON THE TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-ALP:
2-(1-CARBOXY-2-HYDROXY-ETHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / ANTIBIOTIC RESISTANCE / TRANSPOSABLE ELEMENT

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