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Structure paper

TitleStructural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers
Journal, issue, pagesMol. Cell, Year 2025
Publish dateMar 13, 2025 (structure data deposition date)
AuthorsLin C-C / McGinty RK
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.16 - 4.46 Å
Structure data

49676

9nqu

EMDB-49676, PDB-9nqu:
KDM6B-nucleosome structure stabilized by H3K27C-UNC8015 covalent conjugate
Method: EM (single particle) / Resolution: 3.16 Å

EMDB-71691: Consensus map of mouse KDM6B in complex with nucleosome
Method: EM (single particle) / Resolution: 3.16 Å

EMDB-71692: Focused map of NCP+trans-linker DNA
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-71693: Focused map of mouse KDM6B+cis-linker DNA
Method: EM (single particle) / Resolution: 4.46 Å

Chemicals

ChemComp-FE:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-OH0:
N-heptanoyl-N-hydroxy-beta-alanine

Source
  • homo sapiens (human)
  • synthetic construct (others)
  • mus musculus (house mouse)
KeywordsGENE REGULATION/DNA / histone H3K27 demethylation / GENE REGULATION / histone / chromatin / epigenetics / GENE REGULATION-DNA complex

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