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TitleRecognizing Tn and STn Epitopes in Protein Context: Structural Advances in Phage Display Libraries for Tumor-Specific Antibody Discovery
Journal, issue, pagesNat. Chem. Biol., Year 2025
Publish dateFeb 27, 2024 (structure data deposition date)
AuthorsHurtado-Guerrero, R. / Gatos, S. / Gines-Alcober, I. / Macias-Leon, J. / Manuel Gonzalez-Ramirez, A. / Kasapoglu, I. / Veloz, B. / Companon, I. / Ghirardello, M. / Merino, P. ...Hurtado-Guerrero, R. / Gatos, S. / Gines-Alcober, I. / Macias-Leon, J. / Manuel Gonzalez-Ramirez, A. / Kasapoglu, I. / Veloz, B. / Companon, I. / Ghirardello, M. / Merino, P. / Corzana, F. / Blixt, O.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.75 - 2.2 Å
Structure data

PDB-8s6k:
Crystal structure of ScFv-G2D11 complexed to a bis-Tn glycopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-8s6t:
Crystal structure of Fab-3F1 complexed to a bis-STn glycopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-8s6v:
Crystal structure of Fab-2D9 chimera complexed to a bis-Tn glycopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-8s73:
Crystal structure of Fab-antiCD43 monoclonal antibody complexed to a bis-Tn glycopeptide
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-A2G:
2-acetamido-2-deoxy-alpha-D-galactopyranose

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Monoclonal antibody / ScFv-G2D11 / Fab-3F1 / Fab-2D9 / Monoclonal antibodies / Fab-antiCD43 / antigen Tn

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