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TitleDiscovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders
Journal, issue, pagesAcs Med. Chem. Lett., Year 2025
Publish dateFeb 28, 2025 (structure data deposition date)
AuthorsBoerth, J.A. / Schimpl, M. / Lucas, S.C.C. / Zhang, J. / Code, E.L. / Embrey, K.J. / Rawlins, P.B. / Wang, H. / Storer, R.I. / Di Fruscia, P. ...Boerth, J.A. / Schimpl, M. / Lucas, S.C.C. / Zhang, J. / Code, E.L. / Embrey, K.J. / Rawlins, P.B. / Wang, H. / Storer, R.I. / Di Fruscia, P. / Nelson, J.E. / Milbradt, A.G. / Borjesson, U. / Gohlke, A. / Korboukh, V. / Gopalsamy, A.
External linksAcs Med. Chem. Lett. / Search PubMed
MethodsX-ray diffraction
Resolution2.08 Å
Structure data

PDB-9qad:
Crystal structure of the SMARCA2 bromodomain bound to a tricyclic pyrimidoindolone inhibitor (compound 17)
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

Chemicals

PDB-1i45:
YEAST TRIOSEPHOSPHATE ISOMERASE (MUTANT)

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / bromodomain / fragment screening / structure-based inhibitor design

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