| タイトル | Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel |
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| ジャーナル・号・ページ | Nat. Struct. Mol. Biol., Year 2025 |
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| 掲載日 | 2025年1月8日 (構造データの登録日) |
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著者 | Teixeira-Duarte CM / Zeng W / Jiang Y |
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リンク | Nat. Struct. Mol. Biol. / PubMedで検索 |
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| 手法 | EM (単粒子) |
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| 解像度 | 2.44 - 3.19 Å |
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| 構造データ | EMDB-48563, PDB-9mrt: Cryo-EM structure of the human TRPM4 channel in a calcium and PI(4,5)P2 bound open state 手法: EM (単粒子) / 解像度: 2.44 Å EMDB-48603, PDB-9mt8: Cryo-EM structure of the human TRPM4 channel in a calcium bound putative desensitized state 手法: EM (単粒子) / 解像度: 3.19 Å EMDB-48604, PDB-9mta: Cryo-EM structure of the human TRPM4 channel in an apo closed state 手法: EM (単粒子) / 解像度: 2.78 Å EMDB-48605, PDB-9mtc: Cryo-EM structure of the human TRPM4 channel in a ATP bound inhibited state 手法: EM (単粒子) / 解像度: 2.63 Å |
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| 化合物 | ChemComp-PT5: [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho / リン脂質*YM
ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP, エネルギー貯蔵分子*YM
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| 由来 | homo sapiens (ヒト)
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キーワード | TRANSPORT PROTEIN / TRPM4 / Ion channel |
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