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-Structure paper
Title | Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions |
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Journal, issue, pages | to be published |
Publish date | Oct 2, 2022 (structure data deposition date) |
Authors | D'Amico Gonzalez, G. / Handelsman, J. / Centron, D. / Gutkind, G. / Klinke, S. / Power, P. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.35 Å |
Structure data | PDB-8eo5: PDB-8eo6: PDB-8eo7: |
Chemicals | ChemComp-TRS: ChemComp-HOH: ChemComp-CAZ: |
Source |
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Keywords | ANTIMICROBIAL PROTEIN / beta-lactamase precursor / environmental resistome / soil metagenome / ceftazidime / oxyimino-cephalosporin / mutant |