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TitleCrystal structure of EGFR T790M/C797S/L858R mutant in complex with 2,2-dichloro-N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)acetamide
Journal, issue, pagesTo Be Published
Publish dateSep 27, 2024 (structure data deposition date)
AuthorsWang, Y. / Ma, L. / Yang, X.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution3.02 Å
Structure data

PDB-9jq1:
Crystal structure of EGFR T790M/C797S/L858R mutant in complex with 2,2-dichloro-N-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)acetamide
Method: X-RAY DIFFRACTION / Resolution: 3.02 Å

Chemicals

PDB-1ecu:
SOLUTION STRUCTURE OF E2F BINDING DNA FRAGMENT GCGCGAAAC-T-GTTTCGCGC

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / EGFR / inhibitor

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