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TitleCharacterisation of botulinum neurotoxin A mutants with enhanced ganglioside binding properties yielding improved potency
Journal, issue, pagesTo Be Published
Publish dateFeb 1, 2024 (structure data deposition date)
AuthorsMasuyer, G. / Rummel, A. / Stenmark, P.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.6 - 1.9 Å
Structure data

PDB-8rvg:
Structure of the binding domain of BoNT/A mutant Y1117V in complex with the GD1a ganglioside receptor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8rvh:
Structure of the binding domain of BoNT/A mutant Y1117V/H1253K in complex with the GD1a ganglioside receptor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8rvi:
Structure of the binding domain of BoNT/A mutant H1253K in complex with the GM1a ganglioside receptor
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SIA:
N-acetyl-alpha-neuraminic acid

Source
  • clostridium botulinum (bacteria)
KeywordsTOXIN / botulinum neurotoxin / receptor binding / ganglioside

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