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| Title | Structural insights into cohesin cleavage by human separase | 
|---|---|
| Journal, issue, pages | To Be Published | 
| Publish date | Dec 6, 2024 (structure data deposition date) | 
|  Authors | Yu J / Schmidt S / Botto M / Ghent CM / Morgan DO / Boland A | 
|  External links | Search PubMed | 
| Methods | EM (single particle) | 
| Resolution | 2.77 - 3.45 Å | 
| Structure data | EMDB-52288, PDB-9hm7: EMDB-52290, PDB-9hma:  EMDB-52291: Focus-refined map (mask 1) of human separase bound to SCC1 (310-550 aa) and SA2  EMDB-52294: Focus-refined map (mask 2) of human separase bound to SCC1 (310-550 aa) and SA2  EMDB-52295: Consensus map of human separase bound to SCC1 (310-550 aa) and SA2 EMDB-52297, PDB-9hms: EMDB-52298, PDB-9hmv:  EMDB-52300: Focus-refined map of human separase bound to SCC1 (310-550 aa) with a mask on TPR-like domain and SPD  EMDB-52301: Focus-refined map of human separase bound to SCC1 (310-550 aa) with a mask on HEAT-repeat domain  EMDB-52302: Consensus map of human separase bound to SCC1 (310-550 aa) EMDB-52303, PDB-9hn0: EMDB-52306, PDB-9hn4: EMDB-52307, PDB-9hn5: | 
| Chemicals |  ChemComp-ZN:  | 
| Source | 
 | 
|  Keywords | CELL CYCLE / Separase / SCC1 / RAD21 / protease / chromosome segregation / Auto-cleavage / SA1/2 / cohesin | 
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