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Title | Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site |
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Journal, issue, pages | J. Med. Chem., Year 2022 |
Publish date | Aug 14, 2019 (structure data deposition date) |
Authors | Liu, Z. / Li, Y. / Chen, H. / Lai, H. / Wang, P. / Wu, S. / Wold, E.A. / Leonard, P.G. / Joseph, S. / Hu, H. ...Liu, Z. / Li, Y. / Chen, H. / Lai, H. / Wang, P. / Wu, S. / Wold, E.A. / Leonard, P.G. / Joseph, S. / Hu, H. / Chiang, C. / Brasier, A.R. / Tian, B. / Zhou, J. |
External links | J. Med. Chem. / Search PubMed |
Methods | X-ray diffraction |
Resolution | 1.43 Å |
Structure data | PDB-6u0d: |
Chemicals | ChemComp-DMS: ChemComp-POJ: ChemComp-HOH: |
Source |
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Keywords | GENE REGULATION / Bromodomain / Inhibitor / Complex |