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Structure paper

TitleStructural Basis of DNA-Dependent Coactivator Recruitment by the Tuft Cell Master Regulator POU2F3
Journal, issue, pagesTo Be Published
Publish dateJul 6, 2025 (structure data deposition date)
AuthorsAlpsoy, A. / Ipsaro, J.J. / Skopelitis, D. / Pal, S. / Chung, F.S. / Carpenter, S. / Desmarais, J. / Wu, X.S. / Chang, K. / DiMare, M.T. ...Alpsoy, A. / Ipsaro, J.J. / Skopelitis, D. / Pal, S. / Chung, F.S. / Carpenter, S. / Desmarais, J. / Wu, X.S. / Chang, K. / DiMare, M.T. / Harten, E. / Bergman, S. / Kinney, J. / Engelman, J.A. / Bhang, H.C. / Joshua-Tor, L. / Vakoc, C.R.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.7 - 2.79 Å
Structure data

PDB-9pfn:
Structure of POU2F3 POU domains bound to coactivator OCA-T2 and DNA (2.8 angstrom resolution)
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

PDB-9pfo:
Structure of POU2F3 POU domains bound to coactivator OCA-T2 and DNA (2.1 angstrom resolution)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-9pfp:
Structure of POU2F3 POU domains bound to coactivator OCA-T1 and DNA
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-BO3:
BORIC ACID

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / transcription factor / DNA binding / coactivator complex

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