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Structure paper

TitleUnique Structural Features Relate to Evolutionary Adaptation of Cytochrome P450 in the Abyssal Zone
Journal, issue, pagesInt J Mol Sci, Vol. 26, Year 2025
Publish dateApr 3, 2023 (structure data deposition date)
AuthorsHargrove, T.Y. / Lamb, D.C. / Wawrzak, Z. / Minasov, G. / Goldstone, J.V. / Kelly, S.L. / Stegeman, J.J. / Lepesheva, G.I.
External linksInt J Mol Sci / Search PubMed
MethodsX-ray diffraction
Resolution2.73 - 2.9 Å
Structure data

PDB-8sbi:
Crystal structure of human sterol 14 alpha-demethylase (CYP51) in the ligand-free state
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

PDB-9bat:
Crystal structure of sterol 14 alpha-demethylase (CYP51) from deep-sea fish Coryphaenoides armatus (abyssal grenadier) in the ligand-free state
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • coryphaenoides armatus (fish)
KeywordsOXIDOREDUCTASE / MONOOXYGENASE / CYTOCHROME P450 / ENDOPLASMIC RETICULUM / STEROL BIOSYNTHESIS

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