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TitleCrystal structure of the human CDKL5 kinase domain with compound CAF-382
Journal, issue, pagesTo Be Published
Publish dateMar 20, 2024 (structure data deposition date)
AuthorsCapener, J.L. / Kim, J.K. / Richardson, W. / Silvaroli, J.A. / Martinez, G.V. / Thorson, V.C. / Li, J. / Hoyt, K.R. / Satoskar, A.A. / Mallipattu, S.K. ...Capener, J.L. / Kim, J.K. / Richardson, W. / Silvaroli, J.A. / Martinez, G.V. / Thorson, V.C. / Li, J. / Hoyt, K.R. / Satoskar, A.A. / Mallipattu, S.K. / Davidson, A.J. / Zepeda-Orozco, D. / Bajwa, A. / Bullock, A.N. / Axtman, A.D. / Pabla, N.S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-9epu:
Crystal structure of the human CDKL5 kinase domain with compound CAF-382
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

PDB-1h6p:
Dimeristion domain from human TRF2

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / Kinase

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