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TitleDevelopment of highly specific and potent HLA/peptide-targeting DARPin T cell engagers
Journal, issue, pagesTo Be Published
Publish dateMay 17, 2024 (structure data deposition date)
AuthorsVenetz N / Schulte T / Mueller S / Wallden K / Fischer S / Kadri N / Paladino M / Pina N / Radom F / Villemagne D ...Venetz N / Schulte T / Mueller S / Wallden K / Fischer S / Kadri N / Paladino M / Pina N / Radom F / Villemagne D / Bruckmaier S / Cornelius A / Hospodarsch T / Sun R / Chambers BJ / Carroni M / Levitsky V / Sandalova T / Walser M / Achour A
External linksSearch PubMed
MethodsEM (single particle) / X-ray diffraction
Resolution1.76 - 3.1 Å
Structure data

50336

9fe1

EMDB-50336, PDB-9fe1:
Cryo-EM structure of the ternary DARPin NY_1/HLA-A0201/NY-ESO1 complex.
Method: EM (single particle) / Resolution: 3.1 Å

PDB-9epa:
Crystal structure of DARPin NY_1
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / DARPin targeting MHC molecules in complex with tumor-associated peptide antigens

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