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TitleIterative Use of Regiocomplementary Flavin-Dependent Halogenases Gives Access to Unique Halogenation Patterns
Journal, issue, pagesAdv. Synth. Catal., Vol. 367, Year 2025
Publish dateOct 24, 2024 (structure data deposition date)
AuthorsMontua, N. / Scharkowski, B. / Bork, S. / Niemann, H.H. / Sewald, N.
External linksAdv. Synth. Catal. / Search PubMed
MethodsX-ray diffraction
Resolution2.33 - 2.65 Å
Structure data

PDB-9h6m:
Flavin-dependent tryptophan 7-halogenase RebH in complex with 6-bromo-L-tryptophan
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-9h6n:
Flavin-dependent tryptophan 6-halogenase Thal in complex with 6-bromo-L-tryptophan
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-BTR:
6-BROMO-TRYPTOPHAN

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • lentzea aerocolonigenes (bacteria)
  • streptomyces albogriseolus (bacteria)
KeywordsFLAVOPROTEIN / flavin-dependent halogenase / tryptophan halogenase / non-native substrate / unnatural substrate / bound product / enzyme-product complex

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