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TitleMechanism of Action (and Inhibition) of Head-to-Head Terpene Synthases: A Structural Investigation
Journal, issue, pagesTo be Published
Publish dateJan 14, 2010 (structure data deposition date)
AuthorsLin, F.-Y. / Liu, C.-I. / Liu, Y.-L. / Zhang, Y. / Wang, K. / Cao, R. / Wang, A.H.J. / Oldfield, E.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-3lee:
Crystal structure of the human squalene synthase complexed with BPH-652
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-B65:
(1R)-4-(3-phenoxyphenyl)-1-phosphonobutane-1-sulfonic acid

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / isoprenoid synthase fold / Cholesterol biosynthesis / Endoplasmic reticulum / Isoprene biosynthesis / Lipid synthesis / Magnesium / Membrane / Multifunctional enzyme / NADP / Oxidoreductase / Steroid biosynthesis / Sterol biosynthesis / Transmembrane

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