タイトル | SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors |
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ジャーナル・号・ページ | To be Published |
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掲載日 | 2012年11月16日 (構造データの登録日) |
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著者 | Mondal, K. / Regnstrom, K. / Morishige, W. / Barbour, R. / Beroza, P. / Yao, N. / Bova, M.P. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.99 - 2.2 Å |
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構造データ | PDB-4i0h: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors. 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4i0i: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4i0j: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.99 Å |
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化合物 | ChemComp-1BL: (2R)-5-{[(2S,3R)-4-{[1-(3-tert-butylphenyl)cyclohexyl]amino}-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]amino}-2-hydroxy-5-oxopentanoic acid
ChemComp-957: N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({1-[4-(2,2-dimethylpropyl)thiophen-2-yl]cyclopropyl}amino)-2-hydroxypropyl]acetamide
ChemComp-842: N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(1H-pyrazol-1-yl)phenyl]cyclohexyl}amino)propyl]acetamide
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由来 | - homo sapiens (ヒト)
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キーワード | hydrolase/hydrolase inhibitor / BACE / Asp protease / hydrolysis (加水分解) / hydrolase-hydrolase inhibitor complex / Aspartic protease (アスパラギン酸プロテアーゼ) / BACE Asp protease |
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