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Structure paper

TitleStructural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
Journal, issue, pagesJ. Med. Chem., Vol. 42, Page 260-266, Year 1999
Publish dateMay 29, 1998 (structure data deposition date)
AuthorsRoe, S.M. / Prodromou, C. / O'Brien, R. / Ladbury, J.E. / Piper, P.W. / Pearl, L.H.
External linksJ. Med. Chem. / PubMed:9925731
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1bgq:
RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-RDC:
RADICICOL

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsCHAPERONE / ATP-BINDING / HEAT SHOCK / INHIBITOR

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