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Structure paper

TitleStructure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
Journal, issue, pagesJ. Med. Chem., Vol. 41, Page 3426-3434, Year 1998
Publish dateAug 6, 1998 (structure data deposition date)
AuthorsGangjee, A. / Vidwans, A.P. / Vasudevan, A. / Queener, S.F. / Kisliuk, R.L. / Cody, V. / Li, R. / Galitsky, N. / Luft, J.R. / Pangborn, W.
External linksJ. Med. Chem. / PubMed:9719595
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-1boz:
STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-PRD:
N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE

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