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Title3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 95, Page 9518-9523, Year 1998
Publish dateJun 29, 1998 (structure data deposition date)
AuthorsRen, J. / Esnouf, R.M. / Hopkins, A.L. / Jones, E.Y. / Kirby, I. / Keeling, J. / Ross, C.K. / Larder, B.A. / Stuart, D.I. / Stammers, D.K.
External linksProc. Natl. Acad. Sci. USA / PubMed:9689112
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-1rt3:
AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-U05:
6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE

Source
  • human immunodeficiency virus 1
KeywordsNUCLEOTIDYLTRANSFERASE / HIV-1 REVERSE TRANSCRIPTASE / AIDS / NUCLEOSIDE INHIBITOR / DRUG RESISTANCE MUTATION

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