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TitleStructure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 95, Page 4831-4836, Year 1998
Publish dateFeb 18, 1998 (structure data deposition date)
AuthorsLubkowski, J. / Yang, F. / Alexandratos, J. / Wlodawer, A. / Zhao, H. / Burke Jr., T.R. / Neamati, N. / Pommier, Y. / Merkel, G. / Skalka, A.M.
External linksProc. Natl. Acad. Sci. USA / PubMed:9560188
MethodsX-ray diffraction
Resolution1.9 - 2 Å
Structure data

PDB-1a5v:
ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1a5w:
ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1a5x:
ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-Y3:
4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID

ChemComp-HOH:
WATER

Source
  • rous sarcoma virus (strain schmidt-ruppin)
KeywordsHYDROLASE / ENDONUCLEASE / HIV-1 INTEGRASE INHIBITOR

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