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Structure paper

TitleUnusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase.
Journal, issue, pagesJ. Biol. Chem., Vol. 273, Page 8145-8152, Year 1998
Publish dateJan 14, 1998 (structure data deposition date)
AuthorsMazza, C. / Breton, R. / Housset, D. / Fontecilla-Camps, J.C.
External linksJ. Biol. Chem. / PubMed:9525918
MethodsX-ray diffraction
Resolution2.7 - 3.1 Å
Structure data

PDB-1fdu:
HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH ESTRADIOL AND NADP+
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-1fdv:
HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH NAD+
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-1fdw:
HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221Q COMPLEXED WITH ESTRADIOL
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EST:
ESTRADIOL / hormone*YM

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

Source
  • homo sapiens (human)
KeywordsDEHYDROGENASE / 17-BETA-HYDROXYSTEROID / MUTANT / ESTRADIOL / NADP / NAD

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