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TitleCrystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
Journal, issue, pagesBiochemistry, Vol. 37, Page 3677-3686, Year 1998
Publish dateJan 26, 1998 (structure data deposition date)
AuthorsLavie, A. / Konrad, M. / Brundiers, R. / Goody, R.S. / Schlichting, I. / Reinstein, J.
External linksBiochemistry / PubMed:9521686
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3tmk:
CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-T5A:
P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsKINASE / PHOSPHOTRANSFERASE

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