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Structure paper

TitleX-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 94, Page 7857-7861, Year 1997
Publish dateMay 29, 1997 (structure data deposition date)
AuthorsGigant, B. / Charbonnier, J.B. / Eshhar, Z. / Green, B.S. / Knossow, M.
External linksProc. Natl. Acad. Sci. USA / PubMed:9223277
MethodsX-ray diffraction
Resolution2 - 2.55 Å
Structure data

PDB-1yef:
STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH SUBSTRATE ANALOGUE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1yeg:
STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1yeh:
STRUCTURE OF IGG2A FAB FRAGMENT
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PNC:
PARA-NITROBENZYL GLUTARYL GLYCINIC ACID

ChemComp-HOH:
WATER

ChemComp-BPN:
PARANITROBENZYL ALCOHOL

ChemComp-ACT:
ACETATE ION

Source
  • mus musculus (house mouse)
KeywordsCATALYTIC ANTIBODY / IMMUNOGLOBULIN C REGION

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