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Structure paper

TitleStructures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Journal, issue, pagesScience, Vol. 276, Page 955-960, Year 1997
Publish dateMar 25, 1997 (structure data deposition date)
AuthorsMohammadi, M. / McMahon, G. / Sun, L. / Tang, C. / Hirth, P. / Yeh, B.K. / Hubbard, S.R. / Schlessinger, J.
External linksScience / PubMed:9139660
MethodsX-ray diffraction
Resolution2.4 - 2.5 Å
Structure data

PDB-1agw:
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1fgi:
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-SU2:
3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE

ChemComp-HOH:
WATER

ChemComp-SU1:
3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE

Source
  • homo sapiens (human)
KeywordsPROTEIN KINASE / TRANSFERASE / TYROSINE-PROTEIN KINASE / ATP-BINDING / PHOSPHORYLATION / INHIBITOR

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