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TitleSteroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site.
Journal, issue, pagesJ. Mol. Biol., Vol. 254, Page 993-1005, Year 1995
Publish dateAug 3, 1995 (structure data deposition date)
AuthorsMurray, I.A. / Cann, P.A. / Day, P.J. / Derrick, J.P. / Sutcliffe, M.J. / Shaw, W.V. / Leslie, A.G.
External linksJ. Mol. Biol. / PubMed:7500366
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-1qca:
QUADRUPLE MUTANT Q92C, N146F, Y168F, I172V TYPE III CAT COMPLEXED WITH FUSIDIC ACID. CRYSTALS GROWN AT PH 6.3. X-RAY DATA COLLECTED AT ROOM TEMPERATURE
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CO:
Unknown entry

ChemComp-FUA:
FUSIDIC ACID / antibiotic, Antimicrobial*YM

ChemComp-HOH:
WATER

Source
  • shigella flexneri (bacteria)
KeywordsTRANSFERASE (ACYLTRANSFERASE) / CHLORAMPHENICOL / FUSIDATE / STEROID

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