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TitleSelective Inhibition of KRASG13C Reveals an Increased Dependence on Wild-Type RAS Isoforms in Codon 13 RAS-Mutant Cancers.
Journal, issue, pagesCancer Discov, Year 2026
Publish dateJun 23, 2026 (structure data deposition date)
AuthorsSeamon, K.J. / Zhuang, Y. / Yang, Y.C. / Chakraborty, S. / Cregg, J. / Tomlinson, A.C.A. / Gould, A. / Ahler, E. / Maldonato, B.J. / Spradlin, J.N. ...Seamon, K.J. / Zhuang, Y. / Yang, Y.C. / Chakraborty, S. / Cregg, J. / Tomlinson, A.C.A. / Gould, A. / Ahler, E. / Maldonato, B.J. / Spradlin, J.N. / Pota, K. / Weller, C. / Marquez, A. / Wang, Z. / Koltun, E.S. / Knox, J.E. / Gill, A.L. / Smith, J.A.M. / Singh, M. / Jiang, J. / Wildes, D. / Holderfield, M.
External linksCancer Discov / PubMed:42329095
MethodsX-ray diffraction
Resolution1.21 - 2.05 Å
Structure data

PDB-36oi:
Tri-complex of Compound 1, KRAS G13C, and CypA
Method: X-RAY DIFFRACTION / Resolution: 1.47 Å

PDB-36oj:
Tri-complex of Compound 2, KRAS G13C, and CypA
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-36ok:
Tri-complex of RMC-8839, KRAS G13C, and CypA
Method: X-RAY DIFFRACTION / Resolution: 1.21 Å

PDB-36ol:
Crystal Structure of KRAS WT complexed with GMPPNP
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-36om:
Crystal structure of KRAS G13C complexed with GMPPNP
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

PDB-1aol:
FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN

ChemComp-HOH:
WATER

PDB-1dkx:
THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 SELENOMETHIONYL CRYSTALS

ChemComp-CL:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

PDB-1dky:
THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 2 NATIVE CRYSTALS

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CO:
Unknown entry

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / inhibitor / complex / small GTPase / cancer / tri-complex / SIGNALING PROTEIN-INHIBITOR complex

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