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TitleFunctional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life.
Journal, issue, pagesMol. Biol. Evol., Vol. 43, Year 2026
Publish dateJun 12, 2025 (structure data deposition date)
AuthorsNovakova, Z. / Bartosova-Sojkova, P. / Kudlacova, J. / Baselious, F. / Kutilova, Z. / Jaklova, P. / Meleshin, M. / Motlova, L. / Schenkmayerova, A. / Vrkoslav, V. ...Novakova, Z. / Bartosova-Sojkova, P. / Kudlacova, J. / Baselious, F. / Kutilova, Z. / Jaklova, P. / Meleshin, M. / Motlova, L. / Schenkmayerova, A. / Vrkoslav, V. / Strnad, S. / Horacek, N. / Gruber, A. / Zacek, P. / Kroll, S. / Havlinova, B. / Ondrakova, M. / Tuckova, R. / Krunclova, T. / Cvacka, J. / Obornik, M. / Schutkowski, M. / Sippl, W. / Barinka, C.
External linksMol. Biol. Evol. / PubMed:42308148
MethodsX-ray diffraction
Resolution1.06 - 1.51 Å
Structure data

PDB-9rjd:
X-ray structure of Leptospira interrogans Histone deacetylase 11 (HDAC11) in complex with cis-dodec-5-enoic acid
Method: X-RAY DIFFRACTION / Resolution: 1.51 Å

PDB-9rje:
X-ray structure of Chlamydomonas reinhardtii Histone Deacetylase 11 (HDAC11) in complex with hexanoic acid
Method: X-RAY DIFFRACTION / Resolution: 1.06 Å

Chemicals

ChemComp-GOL:
GLYCEROL

PDB-1kd0:
Crystal Structure of beta-methylaspartase from Clostridium tetanomorphum. Apo-structure.

ChemComp-ZN:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-6NA:
HEXANOIC ACID

ChemComp-NO3:
NITRATE ION

Source
  • leptospira interrogans (bacteria)
  • chlamydomonas reinhardtii (plant)
KeywordsHYDROLASE / Histone deacetylase 11 / Leptospira interrogans / class IV HDAC / zinc binding group / UNKNOWN FUNCTION / Chlamydomonas reinhardtii / fatty acid

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