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Structure paper

TitleConstraining regulatory domain dynamics of the Src kinase Fgr increases ATP-site inhibitor sensitivity and impairs bone marrow engraftment.
Journal, issue, pagesCell Rep, Vol. 45, Page 117551-117551, Year 2026
Publish dateJan 14, 2026 (structure data deposition date)
AuthorsGonzalez-Areizaga, G. / Shu, S.T. / Alvarado, J.J. / Shi, H. / Chen, L. / Smithgall, T.E.
External linksCell Rep / PubMed:42301812
MethodsX-ray diffraction
Resolution1.3 - 1.8 Å
Structure data

PDB-10dt:
Crystal Structure of Human Wild-Type Fgr SH3-SH2-Linker Domains.
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-10fs:
Crystal Structure of Human Fgr SH3-SH2-High Affinity Linker Mutant 1 (HAL1) Domains.
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-10fv:
Crystal Structure of Human Fgr SH3-SH2-High Affinity Linker Mutant 2 (HAL2) Domains.
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-10ga:
Crystal Structure of Human Fgr SH3-SH2-High Affinity Linker Mutant 3 (HAL3) Domains.
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-SO4:
SULFATE ION

ChemComp-FLC:
CITRATE ANION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / FGR / SIGNALING PROTEIN / SH3 / SH2

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