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Structure paper

TitleStructural Basis for Potassium Inhibition of WNK Kinases.
Journal, issue, pagesBiochemistry, Year 2026
Publish dateDec 13, 2025 (structure data deposition date)
AuthorsGoldsmith, E.J. / Pleinis, J.M. / Wagner, A. / Mykhaylyk, V. / Akella, R. / Humphreys, J.M. / He, H. / Norrell, L. / Morrison, D.E. / Rodan, A.R.
External linksBiochemistry / PubMed:42186973
MethodsX-ray diffraction
Resolution1.99 - 2.25 Å
Structure data

PDB-9znm:
WNK1/SA kinase domain in complex with potassium formate at 1 Angstrom wavelength
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9zo0:
WNK1/SA kinase domain in complex with cesium formate at 1 Angstrom wavelength
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-9zpn:
WNK1/S382A kinase domain in complex with potassium formate, x-ray wavelength 3.3968 Angstroms
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-CS:
Unknown entry

Source
  • rattus norvegicus (Norway rat)
KeywordsSIGNALING PROTEIN / WNK1 kinase domain / potassium / inactive asymmetric dimer / inhibition / cesium / WNK1 kinase / asymmetric dimer

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