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TitleSNOR promotes translation restart after dormancy.
Journal, issue, pagesNature, Year 2026
Publish dateMay 13, 2026
AuthorsMaciej Gluc / Higor Rosa / Maria Bozko / Lesley A Turner / Cassidy R Prince / Yelena Peskova / Heather A Feaga / Kathleen L Gould / Simone Mattei / Ahmad Jomaa /
PubMed AbstractCellular dormancy enables survival during prolonged nutrient limitation by reversibly suppressing protein synthesis. How inactive eukaryotic ribosomes are reactivated when nutrients return remains ...Cellular dormancy enables survival during prolonged nutrient limitation by reversibly suppressing protein synthesis. How inactive eukaryotic ribosomes are reactivated when nutrients return remains unclear. Here, using high-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe, we identify SNOR, an SBDS domain-containing ribosome-associated factor that binds at the peptidyl transferase centre and contacts the hypusinated loop of eIF5A during glucose depletion-induced dormancy. Rather than acting as a canonical hibernation factor, SNOR licenses dormant ribosomes for rapid translational restart. Upon glucose repletion, SNOR and eIF5A act together to promote efficient recovery of polysomes and exit from dormancy. These findings define a stress-responsive ribosome restart module that couples carbon-source limitation to surveillance of the ribosomal active site and reactivation of protein synthesis.
External linksNature / PubMed:42129552
MethodsEM (subtomogram averaging) / EM (single particle)
Resolution2.8 - 6.7 Å
Structure data

54290

9rvu

EMDB-54290, PDB-9rvu:
in situ S. pombe hibernating ribosome after 7 days of glucose depletion
Method: EM (subtomogram averaging) / Resolution: 3.38 Å

EMDB-54353: In situ Outer Mitochondrial Membrane Tethered Hibernating Ribosomes from S. pombe under glucose depletion
Method: EM (subtomogram averaging) / Resolution: 6.0 Å

EMDB-54354: In situ Free Cytosolic Hibernating Ribosomes from S. pombe under glucose depletion
Method: EM (subtomogram averaging) / Resolution: 6.7 Å

71645

9phc

EMDB-71645, PDB-9phc:
In vitro reconstituted complex of purified S. pombe large ribosomal subunit and SNOR
Method: EM (single particle) / Resolution: 2.8 Å

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • schizosaccharomyces pombe (fission yeast)
  • schizosaccharomyces pombe 972h- (yeast)
KeywordsRIBOSOME / 60S / large subunit / SNOR / pombe / Yeast / Hibernating / Glucose / Cryo-ET / in-situ

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