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TitleDeep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery.
Journal, issue, pagesNat. Biotechnol., Year 2026
Publish dateJun 26, 2025 (structure data deposition date)
AuthorsWang, N. / Yeh, H. / Lai, B. / Perera, J. / Jude, K.M. / Risch, I. / Um, J. / Chen, X. / Xiang, X. / Wang, C. ...Wang, N. / Yeh, H. / Lai, B. / Perera, J. / Jude, K.M. / Risch, I. / Um, J. / Chen, X. / Xiang, X. / Wang, C. / Liu, L.D. / Yang, X. / Paley, M.A. / Khan, A.A. / Garcia, K.C.
External linksNat. Biotechnol. / PubMed:42129507
MethodsX-ray diffraction
Resolution2 - 2.13 Å
Structure data

PDB-9pbg:
TCR 19.2 complex with YEIH-HLA B*27:05
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9pbh:
AS19.2 TCR complex with PSG5-HLA B*27:05
Method: X-RAY DIFFRACTION / Resolution: 2.13 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • escherichia coli (E. coli)
KeywordsIMMUNE SYSTEM / TCR / complex

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