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Structure paper

TitleCryo-EM structure of shutdown human nonmuscle myosin 2A.
Journal, issue, pagesSci Adv, Vol. 12, Issue 16, Page eaed1858, Year 2026
Publish dateApr 17, 2026
AuthorsDavid Casas-Mao / Glenn Carrington / Michelle Peckham /
PubMed AbstractDetermining the high-resolution structure of the widely expressed nonmuscle myosin 2A (NM2A), in its dephosphorylated shutdown state, is important in understanding its regulation and disease roles. ...Determining the high-resolution structure of the widely expressed nonmuscle myosin 2A (NM2A), in its dephosphorylated shutdown state, is important in understanding its regulation and disease roles. In shutdown molecules, the coiled-coil tail wraps around the myosin heads, preventing them from forming filaments and binding to actin. We have solved the shutdown structure of NM2A to a global resolution of 3.0 angstroms in the head region and 6.3 angstroms for the whole molecule. This reveals specific ionic interactions that explain why the path of the coiled coil and the shutdown mechanism for NM2A differ from those of β-cardiac myosin and provides key insight into how specific mutations likely destabilize the shutdown state, leading to disease.
External linksSci Adv / PubMed:41996489 / PubMed Central
MethodsEM (single particle)
Resolution2.98 - 6.3 Å
Structure data

55354

9syu

EMDB-55354, PDB-9syu:
shutdown state non-muscle myosin 2A heads region
Method: EM (single particle) / Resolution: 2.98 Å

55382

9szr

EMDB-55382, PDB-9szr:
shutdown state non-muscle myosin 2A heads region
Method: EM (single particle) / Resolution: 6.3 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
  • gallus gallus (chicken)
  • bos taurus (domestic cattle)
KeywordsMOTOR PROTEIN / Myosin / coiled coil

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