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TitleIn vivo evolution of antibody CR3022 expands cross-neutralization of SARS-CoV-2 variants and informs pan-sarbecovirus immunity.
Journal, issue, pagesCell Rep, Vol. 45, Page 117137-117137, Year 2026
Publish dateJul 25, 2025 (structure data deposition date)
AuthorsFu, Y. / Feng, Z. / Erickson, S.A. / Halfmann, P.J. / Li, L. / Chervin, J.C. / Troxell, C.A. / Sun, J. / Yasuhara, A. / Changrob, S. ...Fu, Y. / Feng, Z. / Erickson, S.A. / Halfmann, P.J. / Li, L. / Chervin, J.C. / Troxell, C.A. / Sun, J. / Yasuhara, A. / Changrob, S. / Huang, M. / Zheng, N.Y. / Yuan, M. / Kawaoka, Y. / Wilson, I.A. / Wilson, P.C.
External linksCell Rep / PubMed:41865371
MethodsX-ray diffraction
Resolution2.54 - 2.81 Å
Structure data

PDB-9psn:
Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-105 and CC12.3
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

PDB-9pso:
Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-622 and CC12.3
Method: X-RAY DIFFRACTION / Resolution: 2.62 Å

PDB-9psp:
Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-1173 and CC12.3
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / COVID-19 / SARS-CoV-2 / Receptor binding domain / Antibody / IMMUNE SYSTEM / IMMUNE SYSTEM-Viral Protein complex / VIRAL PROTEIN-IMMUNE SYSTEM complex

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