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-Structure paper
| Title | Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled Receptor. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Year 2026 |
| Publish date | Sep 26, 2025 (structure data deposition date) |
 Authors | Fisher, E.L. / Dechert Schmitt, A.M. / Tuttle, J.B. / Unwalla, R. / Lovett, G.H. / Kormos, B.L. / Coffman, K.J. / Zhou, D. / Moran, M. / Williams, J. ...Fisher, E.L. / Dechert Schmitt, A.M. / Tuttle, J.B. / Unwalla, R. / Lovett, G.H. / Kormos, B.L. / Coffman, K.J. / Zhou, D. / Moran, M. / Williams, J. / Xiao, J. / LaChapelle, E.A. / Fortin, J.P. / Sheikh, A.Q. / Stevens, K.A. / Kong, J.X. / Hughes, E.A.G. / Esquejo, R.M. / Joaquim, S. / Amar, N.L. / Archambault, D. / Garren, J. / Breen, D. / Jagarlapudi, S. / Dullea, R. / O'Connor, R.E. / Koslov-Davino, E. / Callegari, E. / Dias, J.M. / Lees, J.A. / Borzilleri, K. / Han, S. / Brooks, J. / Vajdos, F.F. / Goyal, A. / Zhang, L. / Zhang, Y. |
 External links | J. Med. Chem. / PubMed:41834467 |
| Methods | EM (single particle) |
| Resolution | 3.08 Å |
| Structure data |  PDB-9yfu: |
| Chemicals |  PDB-1cwb:  ChemComp-HOH: |
| Source |
|
 Keywords | SIGNALING PROTEIN / GPCR / GPR61 / orphan receptor / inverse agonist |
homo sapiens (human)
lama glama (llama)