[English] 日本語
Yorodumi Papers
- Database of articles cited by EMDB/PDB/SASBDB data -

+
Search query

Keywords
Structure methods
Author
Journal
IF

-
Structure paper

TitleB cell imprinting in children impairs antibodies to the haemagglutinin stalk.
Journal, issue, pagesNature, Year 2026
Publish dateMar 11, 2026
AuthorsJiayi Sun / Gyunghee Jo / Chloe A Troxell / Yanbin Fu / Robert Hoezl / Huibin Lv / Hassanein H Abozeid / Qi Wen Teo / Tossapol Pholcharee / Joshua J C McGrath / Siriruk Changrob / Sean A Nelson / Atsuhiro Yasuhara / Min Huang / Nai-Ying Zheng / Jordan C Chervin / Lei Li / Monica L Fernández-Quintero / Johannes R Loeffler / Alesandra J Rodriguez / Jiachen Huang / Olivia M Swanson / Angel Balmaseda / Guillermina Kuan / Lora Campredon / E Kaitlynn Allen / Gabriele Neumann / Nicholas C Wu / Yoshihiro Kawaoka / Florian Krammer / Asuncion Mejias / Octavio Ramilo / Paul G Thomas / Aubree Gordon / Andrew B Ward / Julianna Han / Patrick C Wilson /
PubMed AbstractImmune imprinting or original antigenic sin is a phenomenon whereby the immune system preferentially recalls its initial response to a related, often evolving pathogen after subsequent exposure. ...Immune imprinting or original antigenic sin is a phenomenon whereby the immune system preferentially recalls its initial response to a related, often evolving pathogen after subsequent exposure. Despite its important implications for vaccine development, the causes of imprinting remain unclear. Here, to understand the basis and impact of imprinting by influenza A viruses, we characterized the B cell responses of young children after consecutive first infections with divergent H1N1 and H3N2 strains of influenza. Children had a primary but otherwise similar B cell response to that of adults. Adult B cells commonly cross-reacted with past strains using more stereotyped and mutated immunoglobulin genes, indicating substantial homosubtypic imprinting. In children, after consecutive heterosubtypic primary infections, up to 6% of memory B cells are H1/H3 cross-reactive and bind to the highly conserved central stalk epitope-a lead target for broadly protective vaccine candidates. Over 90% of these B cells had a higher affinity for the imprinting H3N2 strain, resulting in reduced breadth and neutralization potency against H1N1 strains. Mechanistically, the imprinting H3 strains and affected H1 strains shared a residue change in the stalk epitope (D46N) that was central to the nearly universal shift in reactivity, despite differing by only a single atomic group. In conclusion, imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.
External linksNature / PubMed:41813896
MethodsEM (single particle)
Resolution2.62 - 3.12 Å
Structure data

70233

9o8q

EMDB-70233, PDB-9o8q:
Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2)
Method: EM (single particle) / Resolution: 2.62 Å

70234

9o8r

EMDB-70234, PDB-9o8r:
Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Michigan/45/2015 (H1N1)
Method: EM (single particle) / Resolution: 2.96 Å

70235

9o8s

EMDB-70235, PDB-9o8s:
Cryo-EM structure of NI04359_d30_240 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2)
Method: EM (single particle) / Resolution: 2.65 Å

70236

9o8t

EMDB-70236, PDB-9o8t:
Cryo-EM structure of NI04359_d30_240 Fab in complex with influenza virus hemagglutinin from A/Michigan/45/2015 (H1N1)
Method: EM (single particle) / Resolution: 3.12 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • influenza a virus (a/hong kong/485197/2014(h3n2))
  • homo sapiens (human)
  • influenza a virus (a/michigan/45/2015(h1n1))
KeywordsViral protein/Immune System / Influenza / Hemagglutinin / Antibody complex / Viral protein / Viral protein-Immune System complex

+
About Yorodumi Papers

-
News

-
Feb 9, 2022. New format data for meta-information of EMDB entries

New format data for meta-information of EMDB entries

  • Version 3 of the EMDB header file is now the official format.
  • The previous official version 1.9 will be removed from the archive.

Related info.:EMDB header

External links:wwPDB to switch to version 3 of the EMDB data model

-
Aug 12, 2020. Covid-19 info

Covid-19 info

URL: https://pdbj.org/emnavi/covid19.php

New page: Covid-19 featured information page in EM Navigator.

Related info.:Covid-19 info / Mar 5, 2020. Novel coronavirus structure data

+
Mar 5, 2020. Novel coronavirus structure data

Novel coronavirus structure data

Related info.:Yorodumi Speices / Aug 12, 2020. Covid-19 info

External links:COVID-19 featured content - PDBj / Molecule of the Month (242)：Coronavirus Proteases

+
Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)

EMDB accession codes are about to change! (news from PDBe EMDB page)

  • The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.
  • The EM Navigator/Yorodumi systems omit the EMD- prefix.

Related info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator

External links:EMDB Accession Codes are Changing Soon! / Contact to PDBj

+
Jul 12, 2017. Major update of PDB

Major update of PDB

  • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary.
  • This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated.
  • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software).
  • Now, EM Navigator and Yorodumi are based on the updated data.

External links:wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

-
Yorodumi Papers

Database of articles cited by EMDB/PDB/SASBDB data

  • Database of articles cited by EMDB, PDB, and SASBDB entries
  • Using PubMed data

Related info.:EMDB / PDB / SASBDB / Yorodumi / EMN Papers / Changes in new EM Navigator and Yorodumi

Read more