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TitleStructural and biochemical characterization of neutralizing antibodies targeting human papillomavirus type 45.
Journal, issue, pagesStructure, Vol. 34, Page 588-598.e4, Year 2026
Publish dateJul 17, 2025 (structure data deposition date)
AuthorsYanan Jiang / Zhiping Wang / Qin Xu / Shuyue Zhang / Jinfu Su / Hui Sun / Chengzong Zhang / Lizhi Zhou / Tingting Li / Zhibo Kong / Hai Yu / Jun Zhang / Qingbing Zheng / Ying Gu / Ningshao Xia / Shaowei Li /
PubMed AbstractHuman papillomavirus type 45 (HPV45) is a high-risk genotype and the third most prevalent HPV type associated with cervical cancer worldwide, posing a significant public health concern. Although ...Human papillomavirus type 45 (HPV45) is a high-risk genotype and the third most prevalent HPV type associated with cervical cancer worldwide, posing a significant public health concern. Although HPV45 is included in the commercial 9-valent HPV vaccine, its complete virion structure and the molecular basis of antibody-mediated neutralization remain incompletely understood. Here, we report the near-atomic resolution structure of the HPV45 pseudovirus (PsV45) determined by cryo-electron microscopy. We also isolated and structurally characterized several neutralizing monoclonal antibodies (nAbs) targeting PsV45. Our analysis reveals two distinct neutralizing epitopes on PsV45, and these nAbs likely neutralize the virus by a common mechanism involving the inhibition of viral attachment, despite differences in their binding interfaces. Biochemical assays confirmed that antibodies with non-overlapping binding modes can engage PsV45 simultaneously, indicating potential for synergistic combinations. These findings elucidate the structural basis of HPV45 type specificity and provide insights into HPV neutralization mechanisms.
External linksStructure / PubMed:41722563
MethodsEM (single particle)
Resolution3.81 - 4 Å
Structure data

PDB-9vwz:
Local refinement region of HPV45 in complex with antibody A16E6
Method: ELECTRON MICROSCOPY / Resolution: 4 Å

PDB-9vz8:
Local refinement region of HPV45 in complex with antibody 10G2
Method: ELECTRON MICROSCOPY / Resolution: 3.81 Å

PDB-9wlr:
Cryo-EM structure of human papillomavirus type 45
Method: ELECTRON MICROSCOPY / Resolution: 3.95 Å

Source
  • human papillomavirus 45
  • mus musculus (house mouse)
KeywordsSTRUCTURAL PROTEIN/IMMUNE SYSTEM / Human papillomavirus / Cryo-EM / STRUCTURAL PROTEIN-IMMUNE SYSTEM complex / VIRUS LIKE PARTICLE / structural protein / VIRAL PROTEIN

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