EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structures of the honeybee GABA RDL receptor illuminate allosteric modulation.
ジャーナル・号・ページ	Neuron, Year 2026
掲載日	2026年2月6日
著者	Tatiana Labouré / Mayank Prakash Pandey / Eleftherios Zarkadas / Céline Juillan-Binard / Delphine Baud / Jacques Neyton / Thierry Cens / Matthieu Rousset / François Dehez / Pierre Charnet / Hugues Nury /
PubMed 要旨	A large share of insecticides targets insect ion channels. In particular, the GABA RDL (resistant to dieldrin) receptor is targeted by old pore blockers or more recent allosteric modulators binding ...A large share of insecticides targets insect ion channels. In particular, the GABA RDL (resistant to dieldrin) receptor is targeted by old pore blockers or more recent allosteric modulators binding to a cavity of its transmembrane domain. Here, we describe three ligand-binding sites and the associated receptor conformations, using a combination of cryoelectron microscopy (cryo-EM), electrophysiology, and molecular dynamics. The GABA site geometry is well conserved with that of mammalian receptors, in line with the absence of orthosteric insecticide. The transmembrane modulation site, occupied here by abamectin, exists in a closed-pore conformation. We identify a second allosteric transmembrane site using a compound named chrodrimanin B. Structures also reveal the existence of a conformation-dependent PIP lipid site. We anticipate our results to be the starting point for investigations on the physiological modulation of insect GABA receptors. The honeybee receptor structures may also foster the search for species-specific, environmentally benign insecticides.
リンク	Neuron / PubMed:41653930
手法	EM (単粒子)
解像度	2.56 - 3.2 Å
構造データ	54897 9she EMDB-54897, PDB-9she: Structure of the honeybee GABAA RDL receptor with GABA and Abamectin 手法: EM (単粒子) / 解像度: 3.2 Å 54906 9sho EMDB-54906, PDB-9sho: Structure of the honeybee GABAA RDL receptor with GABA 手法: EM (単粒子) / 解像度: 2.56 Å 54929 9sio EMDB-54929, PDB-9sio: Structure of the honeybee GABAA RDL receptor apo state 手法: EM (単粒子) / 解像度: 2.9 Å 54930 9siq EMDB-54930, PDB-9siq: Structure of the honeybee GABAA RDL receptor with Chrodrimanin B 手法: EM (単粒子) / 解像度: 2.96 Å
化合物	ChemComp-ABU: GAMMA-AMINO-BUTANOIC ACID / GABA / 神経伝達物質, 阻害剤YM ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン PDB-1jnz: Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6 resolution ChemComp-PT5: [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho / リン脂質YM PDB-1jn7: Solution Structure of a CCHH mutant of the ninth CCHC Zinc Finger of U-shaped
由来	apis mellifera (セイヨウミツバチ)
キーワード	MEMBRANE PROTEIN / GABAA receptor / insect / neurotransmission / insecticides