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Structure paper

TitleStructural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2.
Journal, issue, pagesCell, Year 2026
Publish dateJan 21, 2026
AuthorsTian Wang / Yiran Wu / Ling Wang / Shanshan Li / Fei Zhao / Lijie Wu / Yue Liu / Jingzi Qin / Qiwen Tan / Junlin Liu / Liting Zeng / Yilin Chen / Shenyuan Gao / Wenqing Shui / Suwen Zhao / Tian Hua / Zhi-Jie Liu /
PubMed AbstractOlfactory receptors (ORs) are a diverse superfamily of G protein-coupled receptors responsible for odor detection that are also implicated in non-olfactory physiological functions. OR6A2, a class II ...Olfactory receptors (ORs) are a diverse superfamily of G protein-coupled receptors responsible for odor detection that are also implicated in non-olfactory physiological functions. OR6A2, a class II OR, selectively senses medium-chain aldehydes and belongs to a cluster of ORs genetically associated with the "soapy" perception of cilantro. It also modulates macrophage-mediated inflammatory responses. Structural studies of ORs have long been challenging. Using a back-mutation strategy, we engineered a functional OR6A2 variant (bmOR6A2) from a consensus OR6 (consOR6). Structures of bmOR6A2 in complex with aldehydes reveal a novel ligand-recognition mechanism involving a reversible Schiff base linkage with residue K, validated by mass spectrometry. By integrating structures of consOR6, molecular dynamics simulations, and functional assays, we identified a conserved DYY triad critical for activation in class II ORs. These findings establish a practical strategy for decoding odorant recognition, offering new insights into olfaction signaling and applications in fragrance and therapeutic development.
External linksCell / PubMed:41570822
MethodsEM (single particle)
Resolution2.54 - 3.33 Å
Structure data

63007

9ldv

EMDB-63007, PDB-9ldv:
Consensus olfactory receptor consOR6 in complex with mini-Golf trimeric protein
Method: EM (single particle) / Resolution: 2.78 Å

63008

9ldw

EMDB-63008, PDB-9ldw:
Consensus olfactory receptor consOR6 bound to alpha-hexyl cinnamaldehyde and in complex with mini-Golf trimeric protein
Method: EM (single particle) / Resolution: 2.62 Å

63009

9ldx

EMDB-63009, PDB-9ldx:
Consensus olfactory receptor consOR6 in complex with mini-Golf trimeric protein
Method: EM (single particle) / Resolution: 2.83 Å

63010

9ldz

EMDB-63010, PDB-9ldz:
Consensus olfactory receptor consOR6 in complex with Gs trimeric protein
Method: EM (single particle) / Resolution: 3.17 Å

63011

9le0

EMDB-63011, PDB-9le0:
Consensus olfactory receptor bmOR6A2 in complex with mini-Golf trimeric protein
Method: EM (single particle) / Resolution: 2.54 Å

63012

9le1

EMDB-63012, PDB-9le1:
Consensus olfactory receptor bmOR6A2 in complex with mini-Golf trimeric protein
Method: EM (single particle) / Resolution: 3.3 Å

63013

9le2

EMDB-63013, PDB-9le2:
Consensus olfactory receptor bmOR6A2 in complex with mini-Golf trimeric protein
Method: EM (single particle) / Resolution: 3.33 Å

Chemicals

PDB-1ejq:
SOLUTION STRUCTURE OF THE SYNDECAN-4 WHOLE CYTOPLASMIC DOMAIN IN THE PRESENCE OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE

ChemComp-CLR:
CHOLESTEROL

PDB-1ejg:
CRAMBIN AT ULTRA-HIGH RESOLUTION: VALENCE ELECTRON DENSITY.

ChemComp-BZQ:
DIPHENYLMETHANONE

ChemComp-OYA:
OCTANAL

PDB-1ejh:
EIF4E/EIF4G PEPTIDE/7-METHYL-GDP

Source
  • homo sapiens (human)
  • synthetic construct (others)
  • mus musculoides (Temminck's mouse)
KeywordsMEMBRANE PROTEIN/IMMUNE SYSTEM / complex / MEMBRANE PROTEIN / GPCR / MEMBRANE PROTEIN-IMMUNE SYSTEM complex

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