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TitleDopamine-Induced Tau Modification Prevents Pathological Phosphorylation and Generates a Distinct Fibril Polymorph.
Journal, issue, pagesJ Am Chem Soc, Year 2026
Publish dateJan 19, 2026
AuthorsZhengtao Liu / Xiang Li / Qianwen Wang / Kaien Liu / Wen Zeng / Danni Li / Kun Zhao / Yeyang Ma / Houfang Long / Shengnan Zhang / Dan Li / Bo Sun / Weidong Le / Chu Wang / Zhuohao He / Wenyan Kang / Weidi Xiao / Cong Liu /
PubMed AbstractAmyloid aggregation of tau is the key pathological event in various tauopathies including Alzheimer's and Pick's disease. Recently, dopamination was identified to modify tau on cysteine, which ...Amyloid aggregation of tau is the key pathological event in various tauopathies including Alzheimer's and Pick's disease. Recently, dopamination was identified to modify tau on cysteine, which protects against tau pathology, yet its structural and functional consequences remain unclear. Here, we show that dopamination of the three-repeat (3R) tau fragment K19 alleviates disease-associated tau phosphorylation and alters the tau fibril structure. Solution NMR analysis reveals that dopamine modification at Cys322 of tau suppresses phosphorylation at several pathogenic sites across the microtubule-binding region. Dopaminated tau also exhibited greatly diminished fibrillization and reduced seeding activity in cells. Finally, we determined the cryo-EM structure of dopaminated tau fibrils at 3.55 Å resolution, revealing a unique fibril polymorph with the smallest core region reported to date for tau. The dopaminated fibril core comprises only 11 residues (centered on the VQIVYK motif) and is stabilized by a minimal hydrophobic interface, explaining its decreased stability compared to that of unmodified tau fibrils. Our results provide atomic-level insight into how dopamine modification imparts a protective effect on tau and underscore the profound influence of post-translational modifications in modulating amyloid protein structure and pathology.
External linksJ Am Chem Soc / PubMed:41555553
MethodsEM (helical sym.)
Resolution3.55 Å
Structure data

63785

9mc2

EMDB-63785, PDB-9mc2:
Cryo-EM structure of dopaminated Tau fibril
Method: EM (helical sym.) / Resolution: 3.55 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / Amyloid

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